In addition, unexpected adverse events, whether coincidental or vaccine-related, will occur that may lead to anxiety and may affect vaccine uptake.

As this vaccine and new squalene-containing vaccines are introduced in other age groups, post-marketing follow-up to detect any vaccine-related adverse events will need to be performed.

An important safety issue related to the varicella vaccine is the impact on the epidemiology of herpes zoster both in vaccinees as well as in individuals previously infected with wild-type varicella.