A sore that does not heal, changes colour, ulcerates or bleeds.
无法治愈剧烈的痛处，颜色转变，溃疡或出血。
2
When the skin suffers to the serious burns, wound, infection and diabetes unprogressive skin ulcerates etc, it become hard problem to repair and rebuild the big area skin defect.
当皮肤遭受严重烧伤、创伤、感染及糖尿病顽固性皮肤溃疡等损害时，大面积皮肤缺损的修复成为棘手的难题。
3
Penetrating atherosclerotic ulcer (PAU) refers to an atheromatous plaque that ulcerates and disrupts the internal elastic lamina, extending through the intima into the aortic media.