释义 |
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医药科学 泛素化 We show that gp78 interacts with both SOD1 and ataxin-3. Overexpression of gp78 promotes the ubiquitination and degradation of these two proteins,whereas knockdown of gp78 stabilizes them. 首先,我们发现了gp78可以与SOD1和ataxin-3这两个蛋白结合,过表达gp78可以促进这两个蛋白的泛素化及降解,而沉默gp78的表达可以稳定这两个蛋白。
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