In two-stageestimate, used orthogonal transformation to estimate aggregate average and fitting constants method to estimate variance which was unbiased.
OBJECTIVE to estimate the population pharmacokinetic parameters of tobramycin by iterative twostage method.
目的用迭代二步法估算肌注妥布霉素的群体药动学参数。
3
For the ratio estimate in two-stage sampling, the bias and mean square errors(MES) of the estimater value have been obtained, and the estimater value of the MSE has been given.