Objective To investigate thiopurine methyltransferase(TPMT) activity distribution in Chinese Han and Yao population.
目的研究巯基嘌呤甲基转移酶（TPMT）活性在中国汉族和瑶族人群中的分布。
2
Conclusion There were no statistically significant differences in Chinese Kazakstan and Chinese Han in distribution of TPMT activity and genotype frequence of TPMT.
结论中国哈萨克族TPMT活性呈正态分布，总TPMT基因突变频率同汉族相比差异无显著性。
3
TPMT genotype correlates well with in vivo enzyme activity in erythrocytes and is closely associated with risk of toxicity. Genetic mutations are responsible for TPMT deficiency.