Elevation NH3 occurs as the toxicmetabolite inhibits the carbomyl phosphate synthase I, preventing the incorporation of NH3 into the urea cycle.
增多的氨作为毒性代谢物抑制了氨甲酰磷酸合成酶,并阻止氨进入尿素循环。
2
In terms of how acetaminophen causes damage and being a toxicmetabolite, the things that would promote acetaminophen toxicity are things that inhibit antioxidants in the liver.
"It is not a metabolite usually thought of as toxic," said Swan, director of the Center for Reproductive Epidemiology at the University of Rochester School of Medicine and Dentistry.