Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.

Although biodegradation is regarded as an economical and efficacious purified method in the treatment of industry waste water and sewage, the high toxicity of nitrobenzene would limit its application.

Then the radiological toxicity of spallation products was studied by applying the concept of annual limit of intake(ALI).