Once disseminate tumor cells pass through the blood-brainbarrier, the brain microenvironment could elicit both inhibiting and promoting effects on tumor colonization and outgrowth.
一旦转移的肿瘤细胞穿过血脑屏障，脑微环境会对肿瘤定植和生长同时发挥抑制和促进作用。
2
Objective To investigate the effect of bradykinin (BK) on tight junction (TJ) of the blood-tumorbarrier (BTB) and interendothelial TJ of capillaries in brain glioma rats.
目的研究缓激肽（BK）对脑胶质瘤大鼠血肿瘤屏障紧密连接的影响。
3
Since most of the chemotherapy drugs cannot pass the blood-brainbarrier, the effect of chemotherapy for braintumor is disappointing.