The traditional method for 2,6-dibromoaniline synthesis is hydrolysis of 3,5-dibromo-4-aminobenzene sulfonamide produced from 4-aminobenzene sulfonamide and hydrobromic acid.
Structure- activity relationship information revealed that 7-aryl-6- azaindole-1- sulfonamide derivatives was more potent than 7-anilino-6-azaindole-1- sulfonamide derivatives.