Esophageal motility problems can occur in patients with progressivesystemicsclerosis (scleroderma) because the submucosa becomes fibrotic.
系统性硬化(硬皮病)病人食管蠕动障碍，因为黏膜下层纤维化。
2
Scleroderma(or progressivesystemicsclerosis):Chronic disease that hardens the skin and fixes it to underlying structures.
硬皮病（亦称进行性全身硬化症）：一种使皮肤变硬并固着于皮下结构的慢性皮肤病。
3
This is the so-called "nucleolar pattern" of staining in which the bright fluorescence is seen within the nucleoli of the Hep2 cells. This pattern is more suggestive of progressivesystemicsclerosis.