Objective To study the effects E. coli purine nucleoside phosphorylase suicidegene on human gastric cancer MKN-45 cells as well as the bystander effect.
Conclusions the double suicidegene driven by KDR promoter has specific killing effect on KDR-expressing gastric tumor cells and venous endothelial cells in vitro.
结论K DR基因启动子可调控双自杀基因系统选择性杀伤表达KDR胃癌细胞及血管内皮细胞。
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Objective To construct a new retroviral vector with double-suicide genes and knockout-inducible SV40T gene, with the aim of optimizing immortalization of hepatocytes.