The lack of the sugarmoiety could cause changes in the structure of the active site of the enzyme resulting in the observed modifications of the KMs.
去除糖基会使葡萄糖氧化酵素的活化位构造改变, 因而产生所观察到的KM值变化。
2
The chemical modification of sugarmoiety in nucleoside or nucleotide is always an important way to discover new lead compounds with anti-viral, anti-tumor and other biological activities.