OBJECTIVE To investigate the association between valproic acid (VAP) plasmaconcentration at steadystate (Css) and CYP2C19 gene polymorphisms for better individualized medication.
目的：寻找丙戊酸药物浓度与CYP2C19基因多态性的关系，以便临床根据患者的基因型进行个体化给药。
2
When VPA is administrated alone, the standardized plasmaconcentration at steadystate (Csss) of VPA is higher in poor metabolism patients than that in normal metabolism patients ( P< 0. 05).