This work was mainly focused on the transcriptional regulation of human ACAT-1 gene P7 promoter activity, and the effect of fatty acids on human ACAT1 gene expression.
Objective: To investigate the role of taurine in acyl-coenzyme a: cholesterol acyltransferase-1 (ACAT-1) expression and activity in THP-1 and THP-1-derived macrophages.
Acyl-CoA: cholesterol acyltransferase(ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from long-chain fatty acyl coenzyme A and cholesterol.