By sequencing the LRP6 gene in affected family members, the scientists found that the mutation caused the substitution of a single aminoacid in the protein the gene produced.
通过对影响家族成员的LRP6基因测序，科学家发现了突变导致该基因产生的蛋白其中一个氨基酸替换了。
2
The five quinazoline compounds were prepared by using 2 amino 4,5 dimethoxy benzoic acid as original material, which underwent ring closing, halogenation and substitution.