Nacer Chadli's poked shot gave Twente hope but a dubious penalty allowed Pavlyuchenko to add a Spurs third and Gareth Bale's late goal sealed victory.
BBC: Tottenham 4-1 FC Twente
2.
Spurs had let a 2-0 lead slip in their opening Champions League group game at Werder Bremen and allowed Twente hope of a comeback as Chadli poked in a shot after the home side failed to clear a free-kick.