The genetic change, known as a partial tandemduplication, is located in a gene called MLL (for mixed-lineage leukemia).
该基因改变,即所谓的部分串联复制,位于MLL(混合血系白血病)基因上。
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A partial tandemduplication is a type of gene mutation that occurs when a section of a gene is repeated, like a stutter in the gene's DNA.
部分串联复制是基因突变的一个类型,当一个基因片断重复时发生,就像停顿基因。
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FLT3 Internal tandemduplication (ITD) and tyrosine kinase domain (TKD) mutations are seen in 30% of AML patients (PTS) and are associated with poor survival.