医药科学

• 维拉帕米

  The inhibitors, cyclosporine A and verapamil,significantly enhanced the uptake amount of 9-nitrocamptothecin (. P<0.05) .

  P-糖蛋白抑制剂维拉帕米能显著增加各段小肠对9-NC的吸收（P<0.05）,在小肠下端更加明显。

• 异搏定

  ALL the five drugs, retinoic acid, tamoxifen, indometacin,verapamil and octreotide, enhanced the inhibition ability of antitumordrugs to both primary cells and PANG-i cell lines.

  乃）维甲酸，三苯氧胺，异搏定可以增加阿霉素在PANC习细胞内积聚。

生物学

• 异搏定

  The results showed that PI-PLC activities were decreased in the tumor cells after treated with verapamil. These changes occurred simultaneously with those changes indexes of calcium homeostasis.

  结果表明经异搏定处理后的A_2细胞PI-PLC活性显著降低,并与钙恒稳的指标基本呈现相应的平行变化趋势。

化学

• 维拉帕米

  MDR results showed that compounds 7 and 10 exhibited moderate reversal activities,and were slightly less potent than those of verapamil against K562 cell line. It is believed that compounds 7 and 10 have MDR activity.

  结果和结论:化合物的结构均由核磁共振氢谱,质谱,红外和元素分析确证,活性实验结果显示,化合物7,10逆转活性略低于维拉帕米,但是仍具有一定的多药耐药逆转活性。