Oncogenes are mutations that cause an excessive stimulation of the cell cycle, while mutations in tumor suppressor genes can result in a loss in function in controlling this excessive activity.
原癌基因的突变导致的过度刺激细胞周期，而突变的肿瘤抑制基因，会导致在这一功能的控制过度活动。
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As Thompson began to study the gene, he found that it was a target for a tumor suppressor gene called p53, which is a major controller of cellactivity in prostate and other cancers.