Objective To investigate the effect and mechanism of sphingosine1-phosphate (S1P) on action potential (AP) and voltage-dependent potassium current (KV) in isolated guinea pig ventricular myocytes.
Sphingosine1phosphate (SPP) is an important second messenger involved in cell growth and cell death.
鞘氨醇1磷酸(SPP)是重要的细胞第二信使,影响细胞的生长和死亡。
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Sphingosine kinase (SPK) is a key enzyme catalyzing the formation of sphingosine1phosphate (S1P), which is a lipid messenger with strong angiogenic activity.