Each cell is linked to this matrix by proteins in its membrane called integrins, and the cell's internal protein skeleton is constantly tugging on these integrins to create a taut, tuned whole.

The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5).

Osteocalcin is a structure protein synthesized by osteoblasts. This protein becomes carboxylated through post-translation processing and plays roles in skeleton development.