Conclusion SLPI can inhibit LPS-induced inflammation in lung of newborn rats.
结论SLPI对LPS致新生大鼠急性肺损伤有抗感染作用。
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Objective To investigate the anti-inflammatory effects of secretory leukocyte protease inhibitor(SLPI) on newborn rats with lipopolysaccharide(LPS)-induced acute lung injury(ALI).
SLPI possesses potent inhibitory activity against neutrophil elastase, cathepsin g, chymase, trypsin and chymotrypsin and play an important role in allergic and inflammatory diseases.