This suggests the diminished expression of NGF and impairment of neuron survival signal transduction pathway may be one of the reason of apoptosis in AD brains.

A major feature of this model is the use of transmission impairment factors that reflect the effects of modern signal processing devices.

The AKT-mediated signal pathway has been shown to be impaired in patients with schizophrenia, and antipsychotic medication may induce AKT activation, to compensate for the impairment.