This is focal segmental glomerulosclerosis (FSGS). An area of collagenous sclerosis runs across the middle of this glomerulus.

This trichrome stain of a glomerulus in a patient with focal segmental glomerulosclerosis (FSGS) demonstrates blue collagen deposition.

The acute model is similar to human minimal change disease, and the chronic model is similar to human focal segmental glomerulosclerosis.