With the removal of oxygen from sicklehemoglobin, the red blood cell deforms into a sickled shape. This sickling damages the RBC membrane and increases the likelihood of rupture and anemia.
随着镰珠蛋白中氧的去除，红细胞变形成镰状，红细胞膜受到破坏，破裂的可能性增加，从而导致贫血。
2
Persons with sickle cell trait (Hemoglobin AS) are much less likely to have this happen.
带有镰状细胞特性(血红蛋白as)的人并不常发生这种情况。
3
Sickle cell disease is a disorder in which blood cells carry a mutation in hemoglobin.