The probable general secretory pathway transmembrane protein (GSP) gene cluster is the center of the type II secretory system.

These data suggest that VWF is sorted to the regulated secretory pathway in endothelial cells much more efficiently than previously reported.

The reactions of the protein N-glycosylation pathway occur along the secretory pathway and most of the entail enzymes localized in the endoplasmic reticulum and the Golgi body.