The current recommended second-linetreatment regimens are complex, of long duration, and require intensive monitoring of adverse events and treatment outcomes.
目前建议采用的二线治疗方案程序复杂、疗程过长，并需要密切监测不良事件和治疗结果。
2
Unless prices for second-line regimens fall significantly, budgetary constraints may put treatment programmes at risk.
除非二线治疗的价格大大降低，否则，预算限制将妨碍治疗方案的实施。
3
Effective treatment requires that all six classes of second-line drugs are available to clinicians who have special expertise in treating such cases.