Objective To study the change of surfactant protein A(SP-A)in bronchoalveolar lavage fluid(BALF)and the relationship with prognosis in newborns with pulmonary hemorrhage.

To dynamically assess the surfactant protein A(SP-A) concentrations in serum of new-bom infants with acute lung injury(ALI), and discuss its clinical significance of SP-A.

Conclusion Evaluating plasma SP-A and SF levels in neonate after mechanical ventilation may help monitor the development and guid the clinical diagnosis and treatment of VILI.