The combination of parenteral antibiotic prophylaxis and prosthetic fixation with antibiotic-impregnated cement protected against septic failure, especially after revision knee arthroplasty.

Both partial and complete revision total knee arthroplasty increased the risk of infection as compared with the risk following primary knee replacement.

G., both of whom had broad expertise in primary and revision conventional and navigated knee arthroplasty, evaluated the clinical relevance and plausibility of the findings.