In 1967 there were the first report of pneumococci that were relatively insensitive to penicillin and by 1981, there were cases of multipledrugresistance.
1967年报道了首例对青霉素相对不敏感的肺炎球菌，到1981多例多药耐药性肺炎球菌被报道。
2
Objective To investigate if CYP3A5 gene is involved in the molecular mechanisms for multipledrugresistance in leukemia cells.
目的探讨CYP3A5基因与白血病细胞多药耐药的关系。
3
Implant infection of Escherichia coli strains showed high levels of resistance, resistance spectrum to expand, and multipledrugresistance. The drug resistant gene is complex and diverse.