After a month, the structure of the brains of these rats ADAPTS to increased dopamine levels, showing fewer of a certain type of dopamine receptor than they used to have and more opioidreceptors.
The research team discovered changes in mu opioidreceptors and dopamine transporters of the brain -- areas important to reward pathways.
研究团队发现在的末梢神经及大脑的多巴胺传输中,区域对酬谢路径非常重要。
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While receptor affinity determines the amount of opioid needed to occupy a given percentage of receptors, it is the intrinsic activity of the opioid that determines its analgesic efficacy.