The LDL receptor defects cause the elevation LDLcholesterol in plasma. This is the main reason for atherosclerosis and is closely related to the risk of coronary heart disease (CHD).

Objective to investigate the effects of oxidized low-density lipoprotein receptor 1 (LOX-1) on secretion of adhesive molecules mediated by ox-LDL in human umbilical endothelial cells (HUVECs).

Early glycated low density lipoprotein (LDL) was not recognized by this receptor. AGEP BSA elevated cytosolic free calcium in a concentration dependent manner.