I've seen people do breath control with gas masks whose rubber edges conform to the face and seal well, regulating the bottom's access to air through the breathing hose.

SATB1 is a nuclear protein well known for its crucial role in regulating gene expression during the differentiation and activation of t cells, making it a key player in the immune system.

This is related to "man's relative short of instinctive regulating in his adaptation to the external world", as well as to man's needs.