Sickle-cell disease is characterized by a modification in the shape of the red blood cell from a smooth, donut-shape into a crescent or halfmoon shape.
镰状细胞病的特征是红血球形状发生突变,由平滑的圆圈形状改变为新月形或半月形。
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In the following decade, color begins to be introduced, and not only that, but the 1936 manicure even includes a half-moon shape carefully formed using a brush and red polish.