释义 |
1 ?原癌基因 原癌基因(proto-oncogenes):癌基因Oncogenes最早发现于逆转录病毒,在动物的正常细胞中也存在与病毒癌基因相似的 DNA 序列称为原癌基因,它们具有正常功能... 2 ?原致癌基因 它们处于正常状态时,称为原致癌基因(proto-oncogenes);发生突变时,就成为数癌基因(oncogenes)。 3 ?基因 原癌基因(Proto-Oncogenes ):癌基因在正常细胞中的形式,对细胞的正常生长有调节作用
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Although many proto-oncogenes and tumor suppressor genes are widely expressed, the mutation of these genes is associated with cancer of specific organs or cell types. 虽然许多原癌基因和肿瘤抑制基因被广泛表达,这些基因的突变与特定的器官或细胞类型的癌有关。 - 2
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes; 氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤; - 3
Under normal circumstances, they are sealed in a fixed state, but in exceptional circumstances, the proto-oncogenes or tumor suppressor genes are activated is lost, people will suffer from cancer. 一般情况下,它们都处于封存不动状态,但在特殊情况下,原癌基因被激活或抗癌基因丢失,人就会患上癌症。
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