To investigate the acute oral toxicity of N, O-carboxymethyl chitosan in chicken and evaluate the security of the drug;

Objective To establish a economic and short-term method of soil fertilizer through the acute health hazard in mice for acute oral toxicity evaluation.

It was actually nontoxic by acute oral toxicity test, did not cause micronucleus formation in mouse bone marrow polychromatic erythrocytes and had weak cumulative effect.