AIM: To establish a new method for calculating the pharmacokinetic parameters of bi-compartmental drugs based on the plasma level of the drug during the intravenous infusion phase.

Only recently have the peroral or dermal use been evaluated. Drugs encapsulated into SLN showed a reduced peak plasma concentration and prolonged therapeutic drug level following oral administration.

Drug products that have similar AUCs but differently shaped plasma-level curves are equivalent in extent but differ in their absorption rate-time profiles.