释义 |
1 ?脯氨酰寡肽酶 超嗜热酶APE1547与脯氨酰寡肽酶(prolyl oligopeptidase,POP)家族成员有很高的同源性,具有两个结构域分别是N端的β-推进器结构域和C端的α/β催化结构域。 2 ?属于脯氨酰寡肽酶家族 超嗜热酯酶APE1547来源于嗜热泉古菌Aeropyrum pernix K1,属于脯氨酰寡肽酶家族(Prolyl oligopeptidase, POP)。APE1547编码582个氨基酸,同时具有酯酶和肽酶活性,是一个双功能酶。 3 ?与脯氨酰寡肽酶 超嗜热酶APE1547与脯氨酰寡肽酶(prolyl oligopeptidase,POP)家族成员有很高的同源性,具有两个结构域分别是N端的β-推进器结构域和C端的α/β催化结构域。
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Method By the international literature, the structure-activity relationships of prolyl oligopeptidase inhibitors, natural active constituents, and clinical studies were summed up. 方法根据国外相关文献,对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。 - 2
Objective to review advances of the study on prolyl oligopeptidase inhibitors, including evaluation of their structure-activity relationships, natural active constituents, and their clinical studies. 目的综述脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床研究等方面的进展。
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