OBJECTIVE: to investigate the affecting factors to the stability of the suspension for oral administration containing potassiumclavulanate and amoxicillin.
目的：对影响克拉维酸钾阿莫西林干混悬剂稳定性的各种因素进行考察。
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METHODS The impurity profiling changes of amoxicillin plus potassiumclavulanate were compared with both amoxicillin and potassiumclavulanate alone by HPLC.
方法采用HPLC，比较阿莫西林和克拉维酸钾单独存在及复方后杂质谱的变化。
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Objective: to establish a high performance liquid chromatography method for simultaneous determination of amoxicillin and clavulanatepotassium in amoxicillin and clavulanatepotassium granules.