Hyaluronidase is a human DNA-derived enzyme that breaks down hyaluronan and temporarily increases its permeability, thereby allowing fluid to be absorbed with the capillary and lymphatic systems.

This paper presents a simplified mathematical model for describing the water block mechanism and its influences, based on Darcy's formula and relative permeability curve and capillary pressure curve.

Citrus bioflavonoids have been shown to improve capillary function by reducing fragility of capillary walls and improving capillary permeability.