Viral hepatitis (B or C) is the most common cause for macronodular cirrhosis. Wilson's disease and alpha-1-antitrypsindeficiency also can produce a macronodular cirrhosis.
The periportal red hyaline globules seen here with periodic acid-Schiff (PAS) stain are characteristic for alpha-1-antitrypsindeficiency (a person with homozygous pi-ZZ genotype).