The globules are intrahepatic collections of alpha-1-antitrypsin that is not being excreted from the hepatocytes.
肝细胞未排泌的α-1-抗胰蛋白酶在肝内聚集，形成小球。
2
Viral hepatitis (B or C) is the most common cause for macronodular cirrhosis. Wilson's disease and alpha-1-antitrypsin deficiency also can produce a macronodular cirrhosis.
The periportal red hyaline globules seen here with periodic acid-Schiff (PAS) stain are characteristic for alpha-1-antitrypsin deficiency (a person with homozygous pi-ZZ genotype).