Iron liberated from hemoglobin, and hemoglobin itself, are associated with the generation of reactive oxygen species (ROS) and reactivenitrogenspecies (RNS).
血色素分解产生的铁离子和血红素本身与反应性氧自由基(ROS)和反应性氮自由基(RNS)的产生相关。
2
Reactive oxygen species can mediate signalling pathways in cardiac hypertrophy and cardiomyocyte apoptosis, and lead to endothelial dysfunction by inactivating nitrogen monoxide.