No effects of risperidone on lithium or valproate exposure were observed, despite a 20% increase in valproate peakplasmaconcentration.
我们没有观察到利培酮合用锂盐或丙戊酸钠的不良反应,尽管在丙戊酸钠上血浆浓度峰值增加20%。
2
Bioavailability determinations based on the peakplasmaconcentration can be misleading, because drug elimination begins as soon as the drug enters the bloodstream.
单靠峰时血浆浓度来确定生物利用度会导致误解,因为药物一进入血流就会开始药物消除。
3
Only recently have the peroral or dermal use been evaluated. Drugs encapsulated into SLN showed a reduced peakplasmaconcentration and prolonged therapeutic drug level following oral administration.