One mechanism of oxidative damage is the nitration of tyrosine residues in proteins, mediated by peroxynitrite breakdown.
FORBES: The Lessons Of Failure: What We Can Learn From Bapineuzumab's Blowup
2.
Although carbonyl formation is a major oxidative modification induced by peroxynitrite, nitration of tyrosine residues is an indicator of peroxynitrite involvement.
FORBES: The Lessons Of Failure: What We Can Learn From Bapineuzumab's Blowup