Treatment of AMPK-DN mice with adiponectin failed to phosphorylate cardiac acetyl-CoA carboxylase as it did in WT mouse heart.
给予AMPK - DN组鼠脂连素处理未能磷酸化心脏乙酰辅酶A羧化酶,而在WT组鼠中可以实现。
2
An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2 phosphorylate key proteins to elicit cell-cycle blocks.
Polo-like kinases also phosphorylate the cohesin subunit SCC1, causing cohesin displacement from chromosome arms that allow for proper cohesin localization to centromeres (7).