Working with Anil Mehta, a chemistry post-doctoral fellow, Childers tagged one end of peptide chains with an NMR label, and then allowed them to assemble to see if the ends would interact.
The importance of chemistry of protein and peptide pegylation has attracted more and more attentions as more PEG conjugates have reached late phase clinical trials.
随着聚乙二醇化蛋白质和肽类进入临床试验阶段，聚乙二醇化化学越来越引起研究者的重视。
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This review focuses on peptide segment ligation for synthesis of peptides and proteins. Ligation is a new methodology in peptide and protein synthesis chemistry.