Most scientific experts consider this benefit "progression-freesurvival," sufficient for full approval, and many oncologists have been using Avastin as an "off-label" drug for this purpose.
Thus, surrogate endpoints like response rate and progression-freesurvival are commonly accepted, although all parties involved realize the risk involved.
因此，替代终点如反应率和无进展生存率被普遍接受，尽管各方意识到风险所在。
3
The median progression-freesurvival period with the drug combination was 11.8 months, twice as long as the 5.9 months achieved with paclitaxel alone.