Secondary endpoints will include death from any cause, changes in left ventricular size and function, renal function, changes in neurohormonal levels and quality-of-life assessments.

Background: Obstructive sleep apnea has a high prevalence and is characterized by acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of mi during the night.

The results showed that amrinone could inhibit significantly the neurohormonal system which was activated when severe heart failure happened. and it had a good therapeutic effect for heart failure.