| 释义 |
nucleotide excision repair - 一种DNA修复方法，通过移除DNA中受到化学、辐射等因素破坏的碱基对，使细胞免于受到有害变异的影响
1 ?核苷酸切除修复 ...瘤的化疗,是消化系统肿瘤化疗的传统药物之一,但耐药性的产生严重影响其疗效,目前认为核苷酸切除修复(nucleotide excision repair,NER)是铂类药物耐药的重要机制之一,因其导致耐药的主要机理为清除大规模铂类化舍物所致DNA螺旋扭曲. 2 ?核苷酸剪切修复 ...关键词】 ERCC1 XPC 核苷酸剪切修复 局部晚期宫颈癌 新辅助化疗 [gap=2457]Key words: ERCC1; XPC; nucleotide excision repair; locally advanced cervical cancer; neoadjuvant chemotherapy .. 3 ?修复 DNA的稳定性依赖于DNA的修复能力，核苷酸的切除修复（nucleotide excision repair）是人类DNA的主要修复方式，此外还包括复制后修复、光修复。切除修复过程： 4 ?修复途径 而核酸切除修复途径(nucleotide excision repair, NER)是DNA交联损伤的主要修复途径,其中ERCC1是NER限速酶。研究显示ERCC1第118位密.
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Plant could repair DNA damage induced by UV-B through many methods, mainly included light-repair, base excision repair, nucleotide excision repair and recombination repair etc. 植物可以通过多种途径来修复紫外诱导的DNA损伤，主要包括光修复、碱基切除修复、核苷酸切除修复和重组修复等。 - 2
AIM: To investigate the expression of nucleotide excision repair gene ERCC1 and its relationship with PAH (polycyclic aromatic hydrocarbons) -dna adducts in lung cancer tissues. 目的：探讨核苷酸切除修复基因ERCC1在肺癌中的表达及其与多环芳烃(PAH) - DNA加合物的关系。 - 3
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways. 由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
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